Abstract

Background: Sepsis remains a major cause of mortality worldwide. Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) have been proposed as predictors of sepsis severity and outcomes.

Objectives: This study aimed to analyze the dynamics of NLR, CRP, and PCT clearance in relation to mortality risk in intensive care unit (ICU) patients diagnosed with sepsis.

Methods: This retrospective cohort study included 64 septic patients admitted to the ICU of Dr. Wahidin Sudirohusodo Hospital from August to October 2024. Clinical and laboratory data were collected on days 1 and 5. Patients were classified into survivor and non-survivor groups.

Results: NLR and PCT values were significantly higher in non-survivors (p<0.05). CRP levels did not differ significantly. Logistic regression showed that NLR and PCT clearance on day 5 were independently associated with increased mortality risk (p<0.05).

Conclusion: NLR and PCT may serve as useful biomarkers for mortality prediction in ICU patients with sepsis. Monitoring their dynamics can help guide clinical decision-making.

Faisal Muchtar, Syafri Kamsul Arif, Mordekhai Leopold Laihad, Haizah Nurdin, Asvin Nurulita, Rezki Hardiyanti Taufik, Priady Wira Prasetia