Abstract
Objective: This study aimed to investigate the relationship between estimated plasma volume values and syndecan-1 levels in relation to Sequential Organ Failure Assessment (SOFA) scores in septic patients in the Intensive Care Unit (ICU).
Design: Cross-sectional study.
Setting: Intensive Care Unit at Wahidin Sudirohusodo Hospital, Makassar.
Patients and participants: A total of 30 patients with sepsis criteria aged 18-65 years and hospitalized in the ICU.
Measurement and results: Measurement of estimated plasma volume status (ePVS), syndecan-1, and SOFA score in the first 24 hours and 72 hours after sepsis diagnosis was established. There was a significant and positive relationship between syndecan-1 and SOFA score measured in the first 24 hours and 72 hours after sepsis diagnosis, with a p-value <0.05. Estimated plasma volume was not significantly related to the SOFA score measured in the first 24 hours and 72 hours after sepsis diagnosis, with a p-value >0.05.
Conclusions: Decreased syndecan-1 levels were strongly associated with decreased SOFA scores in septic patients in the ICU.
Lukman Husein Semarang, Faisal Muchtar, Haizah Nurdin, Hisbullah, Andi Alfian Zainuddin, Syamsul Hilal Salam, Andi Adil
