Abstract
Objective: This study aimed to ascertain how procalcitonin levels and the systemic immune-inflammation index (SII) correlate in patients with sepsis.
Design: This was a retrospective cross-sectional analysis. Procalcitonin level and total blood count information were taken from the patient’s medical file. Neutrophils, lymphocytes, and platelets were used to calculate the SII value.
Setting: We conducted this study in the Medical Record Installation at Wahidin Sudirohusodo Hospital from January to December 2023.
Patients and participants: Two hundred nineteen septic patients’ information was taken from the patient’s medical files.
Measurement and results: The majority of individuals died (64.8%), were over 65 years old, and were male (58.9%). In nonsurvival sepsis, the median procalcitonin was significantly higher (27.15) (p<0.05), and the median SII was significantly lower (2065.7) (p<0.01). There was a significant negative correlation between SII values and procalcitonin levels; the higher the procalcitonin level, the lower the SII value (p<0.01, R<0.250). SII’s cut-off from the receiver operating characteristic (ROC) curve was roughly 1131.26×109/l, indicating that it might be prognostic, with a sensitivity of 83% and a specificity of 25%.
Conclusion: The SII value decreases with increasing procalcitonin levels. With an 83% sensitivity, the initial SII value with a cut-off of 1131.26×109/l can be utilized as a marker for sepsis prognosis.
Uleng, Ismirawati, Asvin Nurulita
