Abstract
Objective: This study aimed to determine the relationships among procalcitonin (PCT), C-reactive protein (CRP), pancreatic stone protein (PSP), and the Sequential Organ Failure Assessment (SOFA) score in septic patients during the first 72 hours of intensive care unit (ICU) care.
Design: Prospective observational cohort with a two-time-point.
Setting: Intensive Care Unit of Dr. Wahidin Sudirohusodo General Hospital, Makassar, from November 2024 to February 2025.
Patients and participants: 40 patients with sepsis meeting Sepsis-3 criteria were enrolled in the study.
Measurements and results: PSP, PCT, and CRP levels were measured within the first 72 hours after sepsis diagnosis, analyzed using an enzyme-linked immunosorbent assay (ELISA) kit, and correlated with the SOFA score using the Spearman test. The results showed that all three biomarkers were positively correlated with the SOFA score. PCT showed a strong and significant correlation with SOFA (r=0.663, p<0.001), CRP also showed a strong and significant correlation (r=0.650, p<0.001), while PSP showed a moderate but significant correlation (r=0.430, p=0.004). PCT and CRP were significantly associated with a higher risk of mortality (p<0.05), but not significantly in PSP (p>0.05).
Conclusion: PCT and CRP have potential as markers of prognosis and severity of sepsis in the early phase of intensive care, and PSP has potential as a marker of severity and higher risk of mortality in sepsis.
Frangky Hamsyah, Haizah Nurdin, Hisbullah, Faisal, Syamsul Hilal Salam, Ari Santri Palinrungi
