Abstract
Objective: To compare the Acute Physiological And Chronic Health Evaluation II (APACHE II) scores and lactate/albumin ratio (LAR) in relation to mortality rates among septic patients in intensive care units (ICU).
Design: Retrospective case-control study.
Setting: Research from medical record data at the ICU of Dr. Wahidin Sudirohusodo Hospital in January-December 2023.
Patients and participants: 147 septic patients were collected using the total sampling technique.
Measurements and results: Patients were identified based on 28-day mortality and APACHE II and LAR measurements. APACHE II and LAR were significantly greater in deceased patients than survivors within 28 days of sepsis diagnosis (p<0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of the APACHE II was 0.784 (95% CI=0.704-0.864, p<0.001) with a cut-off of 21.5, sensitivity of 71.6%, and specificity of 75.6%. The AUC of LAR was 0.733 (95% CI=0.651-0.815, p<0.001) with a cut-off of 0.955, sensitivity of 67.6%, and specificity of 68.9%.
Conclusions: The APACHE II and LAR were good predictors of 28-day sepsis mortality, whereas the APACHE II obtained better diagnostic accuracy, sensitivity, and specificity than the LAR.
Andi M. Irsyad Sulkifli Mangga Barani, Syamsul Hilal Salam, Haizah Nurdin, Andi Husni Tanra, Faisal Muhtar, Ari Santri Palinrungi
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Comparison between APACHE II score and lactate:albumin ratio in predicting mortality in septic patients
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