Abstract
Introduction: Sepsis is defined as life-threatening organ dysfunction caused by dysregulation of the body’s response to infection. Sepsis can cause multiple organ dysfunctions, including kidney dysfunction, leading to sepsis-related acute kidney injury (S-AKI). Recent studies have found that neutrophil gelatinase-associated lipocalin (NGAL) can be a biomarker responsive to tissue stress and injury to the nephron, so acute kidney damage is recognized more quickly. This biomarker also functions as a monitor of development and recovery, and predicts the final outcome.
Method: This study was a prospective observational study to see the relationship between NGAL levels as a predictor of AKI incidence in septic patients in the intensive care unit (ICU). The research sample was taken according to the inclusion and exclusion criteria, and the sample size was 40.
Results: NGAL levels >150 ng/ml with the occurrence of sepsis with AKI were found in 32 (94.1%) samples, and sepsis without AKI in 2 (5.9%) samples. NGAL levels <150 ng/ml with the occurrence of sepsis with AKI was 1 sample (16.7%), with sepsis without AKI in 5 (83.3%) samples. It was found that NGAL had a relationship with the occurrence of sepsis with AKI (p<0.001, specificity 96%, specificity 71%, positive predictive value [PPV] 93%, negative predictive value [NPV] 94%, and area under the curve [AUC] 86%).
Conclusion: There was a relationship between NGAL and the incidence of AKI, and it had a specificity of 97%, specificity of 71%, PPV of 94%, NPV of 83%, and AUC of 86%.
Miftah Furqon Aulia, Andriamuri Primaputra Lubis, Ester Lantika Silaen, Juliandi Harahap
