Abstract
Objectives: In the current study, we aimed to evaluate the prognostic value of measuring C-reactive protein (CRP), procalcitonin (PCT), and mid-regional proadrenomedullin (MR-ProADM) at 2-time points (i.e., day 1 and day 5) in predicting 28-day mortality.
Design: This was a cohort, cross-sectional study.
Setting: In Zagazig University Hospitals from June 2019 to June 2020 as a collaboration between Clinical Pathology Department and the Intensive Care Unit.
Patients and participants: The study included 32 septic intensive care unit (ICU) patients.
Measurements and results: Blood samples (for serum separation) were collected from each patient on the first day of sepsis diagnosis (day 1) and then 5 days later (day 5). The serum was analyzed for CRP, PCT, and MR-ProADM. At the end of 28 days of observation, patients were classified as survivors or non-survivors. Comparing the level of each biomarker between survivors and non-survivors on day 1 and day 5 showed that only MR-ProADM was significantly different between groups at both measuring points. Meanwhile, PCT showed a significant difference only on day 5. On day 1, using 245.9 pg/ml as a cutoff point, MR-ProADM had 75% sensitivity and 85.7% specificity. Meanwhile on day 5, using 124.4 pg/ml as the cutoff for MR-ProADM, it had 80% sensitivity and 85.2% specificity.
Conclusion: Based upon our findings in our study setting, MR-ProADM was a good mortality predictor for ICU patients with sepsis on both the first and fifth day of sepsis detection.
Alaa A. Fahmy, Mervat Mostafa Azab, Ghada Elsayed Amr, Heba M. Matar, Amany Mohyeldin Sediq
