Background: Aggressive fluid resuscitation is commonly administered in septic patients as recommended by Surviving Sepsis Campaign. However, positive fluid cumulative balance resulting in fluid overload is correlated with various complications such as acute kidney injury, acute respiratory distress and delayed wound healing.
Case report: This report presents four septic patients with fluid overload and acute kidney injury who underwent active de-resuscitation aiming central venous pressure between zero and two mmHg.
Discussion: In all patients, central venous pressure guided de-resuscitation was associated with systemic oxygenation improvement (arterial lactate dropped from 8.3 to 0.8 mmol/l, from 5.3 to 0.3 mmol/l, from 3.5 to 0.5 mmol/l, and from 3.3 to 0.7 mmol/l) and acute kidney injury resolution without hemodynamic instability and elevated lactate level. Negative cumulative balance is associated with a significant reduction of norepinephrine dose.
Conclusion: A de-resuscitation strategy based on the target of central venous pressure 0-2 mmHg is a safe and effective procedure that resulted in improvement in hemodynamics, serum lactate, renal function and also systemic oxygenation.