One of the key treatments for obstructive sleep apnea (OSA), the initiation of nocturnal continuous positive airway pressure (CPAP), is the treatment of choice. (1) The use of CPAP is indicated after ruling out any anatomical abnormalities. The use of CPAP can improve gas exchange in the alveolocapillary membrane and decreases the work of breathing by keeping the upper airway open. Chronic CPAP users may be at risk of complications when undergoing skull-based surgery. (2) Our objective is to present a case of a patient who developed pneumocephalus following skull base meningioma resection.