Critical Care and Shock

The relationship between neutrophil-lymphocyte ratio and quick sequential organ failure assessment on Covid-19 patients’ mortality

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Introduction: Coronavirus disease 19 (Covid-19) transmission could lead to varied symptoms, from mild, moderate, severe, and critical symptoms that require intensive care. The transmission can be predicted by the neutrophil-lymphocyte ratio (NLR) and the quick Sequential Organ Failure Assessment (qSOFA) value when the patient is admitted to the emergency department (ED) to anticipate the high mortality rate.

Methods: This study was an observational analytic study with a retrospective cohort study to analyze the medical records of Covid-19 patients from July to December 2020 at the North Maluku Referral Hospital. NLR and qSOFA were calculated on admission to the ED.

Results: The total of Covid-19 patients was 268 (245 were alive and 23 died). There was an increase in NLR in patients who died with a cut-off value of 12.42, a sensitivity of 82.6%, and a specificity of 89% (area under the receiver operating characteristic [ROC] curve [AUC] 0.894; p<0.001). There was also an increase in qSOFA with a cut-off of 2, sensitivity 73.9%, and specificity 85.3% (AUC 0.861; p<0.001). The mortality of patients with qSOFA ³2 was 32.1%.

Conclusion: There was a significant relation between NLR and qSOFA with mortality that happened in Covid-19 patients.