Critical Care and Shock

Blood plasma plasmalogens and fatty acids in multiple organ dysfunction syndrome



Introduction: Changes in fatty acid composition as well as in a level of blood plasma plasmalogens in cases of various pathological conditions are evidences of lipid metabolism disorders and can indicate their reasons and degree. The objective of this study was to analyze fatty acids and plasmalogens of blood plasma in patients with multiple organ dysfunction syndrome (MODS).

Methods: Fatty acid ethyl esters and diethyl acetals of fatty aldehydes obtained during sample preparation were analyzed by capillary gasliquid chromatography.

Results: Marked changes in the plasma fatty acid composition and plasmalogen levels in pa tients with MODS were detected.

Conclusions: Based on the detected significant reduction in the plasmalogen levels of blood plasma, a conclusion was made about possible presence of peroxisome dysfunctions in patients with MODS. Peroxisome dysfunction may be one of the reasons of violation of detoxification processes, fatty acids oxidation disorder, prolongation and intensification of the inflammatory process, neurological disorders, and decreased blood antioxidant capacity. The assumption was made about an important role of fatty acids in disturbance of systemic hemodynamics, assessment of a degree of lipid metabolism disorders and activity of сatabolic response.

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