Choriocarcinoma is a rare disease in the young population. It uncommonly occurs after a normal full term pregnancy or in men. In the report, we presented two uncommon manifestations of choriocarcinoma. In the first case, a young woman developed choriocarcinoma metastasis after a normal full term pregnancy. She was treated with chemotherapy after the diagnosis and finally recovered. In the second case, a young man suffered from severe respiratory failure due to lung pathology and finally succumbed. The diagnosis of pulmonary choriocarcinoma could only be made after postmortem examination. Both cases illustrated atypical presentations of this malignant but curable disease.