Critical Care and Shock

Anaphylaxis and rhabdomyolysis. Any early relationship?



Introduction: Rhabdomyolysis (RML) had been identified in different traumatic and non-traumatic conditions; few reports described its association with anaphylaxis. We report two cases of anaphylaxis both complicated with RML.

Aim of the work: To discus the possible casual relation between anaphylaxis and RML and so the value of early screening of creatine phosphokinase (CPK) in patients with anaphylaxis.

Setting: Two patients were enrolled in a multidisciplinary intensive care unit.

Results: Both patients survived, both developed RML shortly after admission, evidenced by 5-fold or greater increase in serum CPK. They had transient hypotension through the presentation, but none of them had persistent shock requiring vasopressors or complicated with acute renal failure.

Conclusion: We observed rapid increase in serum CPK in our two cases suggesting the potential benefits of early assessment of CPK in such patients which may amplify early goal guided management and avoiding logistic organ dysfunction.

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