Critical Care and Shock

Statin use and morbidity outcomes in septic shock patients: a retrospective cohort study

Abstract

Objective: The purpose of this study is to determine the association between statin use and septic shock morbidity.

Design: A retrospective, single center chart review.

Location: Intensive care unit of an urban tertiary care hospital.

Patients and participants: Convenience sample of 150 patients diagnosed with septic shock in the hospital intensive care unit (ICU).

Intervention: The cohort of subjects on statin therapy prior to ICU admission was compared to the cohort that was not on prior statin therapy. The primary morbidity outcome between the two groups was duration of vasopressor support.

Results: Mean duration of vasopressor support was 233±SE 94 hours in the statin group and 126±SE 20 hours in the non-statin group (p=0.269). ICU length of stay was 12 days in the statin group and 11 days in the non-statin group (p=0.600). Hospital length of stay was 44 days in the statin group and 39 days in the non-statin group (p=0.851). ICU mortality and hospital mortality was not statistically different between the two groups.

Conclusion: Prior statin use was not associated with decreased duration of vasopressor support or morbidity in septic shock patients. Conversely, there were trends towards worse outcomes in patients on statins prior to admission.