Crtical Care and Shock Journal

Life-threatening hyponatremia in marathon runners: The Varon-Ayus syndrome revisited




Life-threatening hyponatremia can occur when sodium concentration falls to 125 mmol/L or less. Symptoms usually do not depend on the absolute sodium concentration but on the rate of fall. Estimates of mortality in acute hyponatremia are as high as 50%. Marathon runners are at particular risk of developing a syndrome which consists of severe hyponatremia, pulmonary edema and cerebral edema as originally described by Varon and Ayus. This syndrome, if not managed appropriately has a very high morbidity and mortality.

Pilar Acosta, Joseph Varon


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June 2024, Volume 27 Number 3
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